Merhaba Misafir

Haplophyllum buxbaumii ekstresinin skuamöz hücreli karsinoma üzerine apoptotik etkileri

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Purpose: Oral cancers are malignant neoplasms affecting the structures or tissues in the mouth and oral squamous carcinoma is the most common neoplasm of the skin, lips and oral cavity mucous membrane. It has been suggested that Haplophyllumbuxbaumii, which is a perennial herbaceous plant, has antioxidant activity. The aim of this in vitro study is to investigate the anticancer effects of Haplophyllum on oral squamous cancer cell lines. Materials and Methods: The effects of Haplophyllumbuxbaumii plant extract on squamous cell carcinoma were evaluated by Cell viability Assay, Total Protein Quantification and by activity of cleaved caspase-3, Bax and Bcl-2 determined by ELISA method. Results: The results of the tests showed that Haplophyllum extract application reduced the viability of squamous cell carcinoma cells while activating the apoptotic pathway when compared to the controls. Conclusion: The findings of the study suggest that Haplophyllumbuxbaumii plant extract may have some anticancer potential to contribute to the studies on squamous cell carcinoma therapy.

Yayınlandığı Kaynak : Cukurova Medical Journal
  • Yıl : 2020
  • DOI : 10.17826/cumj.695880
  • Cilt : 45
  • ISSN : 2602-3032
  • Sayı : 3
  • eISSN : 2602-3040
  • Sayfa Aralığı : 1152-1156
  • IO Kayıt No : 118467
  • Yayıncı : Çukurova Üniversitesi Tıp Fakültesi