Merhaba Misafir

Fosfomycin and nitrofurantoin susceptibilities of Escherichia coli and Klebsiella pneumoniae isolates producing extanded spectrum Beta-lactamase causing urinary tract infections

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Introduction: Escherichia coli and Klebsiella pneumoniae are the most common pathogens causing urinary tract infection. Increasing numbers of extended spectrum β-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates in urinary tract infection, limits to treatment options. The aim of this study was to determine the susceptibility of fosfomycin and nitrofurantoin to extended spectrum beta-lactamase producing Esherichia coli and Klebsiella pneumoniae isolates in hospitalized patients, contribute to the planning of empirical treatment of urinary tract infection. Methods: A total of 14.383 midstream urine samples sent to Tokat Gaziosmanpasa University Hospital Microbiology Laboratory between January 2016 and December 2017 were evaluated retrospectively in this study. Isolates were identified by conventional methods (Gram stain, motility, biochemical tests etc) and VITEK 2 (bioMérieux, France) automated system. Antibiotic susceptibilities were detected by VITEK 2 automated system. Results: Extended spectrum β-lactamase producing 85 Esherichia coli and 23 Klebsiella pneumoniae isolates, sent from hospitalized patients were included in the study. The strains were most frequently isolated in the intensive care units (46.3%). The most effective antibiotics against to Esherichia coli and Klebsiella pneumoniae were carbapanems and susceptibility rates were %100 and %87, followed by fosfomycin 98 % and 83 %, nitrofurantoin 94 % and 30.4% respectively. Discussion and Conclusion: Fosfomycin was found effective treatment option against extended spectrum β-lactamase producing Esherichia coli and Klebsiella pneumoniae in urinary tract infections. However, nitrofurantoin is thought to be more suitable for use in urinary tract infections caused by Esherichia coli isolates producing expanded spectrum β-lactamase.

Yayınlandığı Kaynak : Journal of Contemporary Medicine