Merhaba Misafir

Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations


Objective: The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas. Material and Methods: For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used. Results: A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group. Conclusion: The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma. (J Turk Ger Gynecol Assoc 2018; 19: 128-31)

Yayınlandığı Kaynak : Journal of the Turkish-German Gynecological Association
  • Yıl : 2018
  • DOI : 10.4274/jtgga.2018.0002
  • Cilt : 19
  • ISSN : 1309-0399
  • Sayı : 3
  • eISSN : 1309-0380
  • Sayfa Aralığı : 128-131
  • IO Kayıt No : 76553
  • Yayıncı : Turkish-German Gynecological Association