Merhaba Misafir

Microwave synthesis of new 3-(alkylthio)-5-(thiophen- 2-ylmethyl)-1,2,4-triazol-4-amines


Objective: The aim of this work is to synthesize 3-(alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4- amines by the Milestone Flexi Wave microwave synthesis system and to prove structure synthesized compounds. Material and Method: The initial compounds 3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-5-thioles (1-5) were synthesized at the Department of Toxicological and Inorganic Chemistry of the Zaporizhzhya State Medical University (Ukraine). Milestone Flexi Wave microwave synthesis system was used to synthesize 3- (alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4-amines. The elemental analysis of synthesized compounds was established by the universal analyzer Elementar Vario L cube (CHNS). The 1H spectra (at 400 MHz and 100 MHz) were recorded in DMSO-d6 on a Varian MR-400 spectrometer and analysed with ADVASP™ Analyzer program. The completeness of the reactions and the individuality of the resulting compounds were controlled by the gas chromatograph Agilent 7890B with a 5977B mass spectrometry detector. Result and Discussion: The reaction was carried out in an alcoholic medium by adding a catalytic amount of HCl to 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. Methyl and i-propyl alcohols were used as alcohols. The mixture was heated for 45 minutes at a temperature of 150°C, a pressure 14.4 bar, ΔMW = 200 W. The signals of 1H NMR for (4a-b, 6a-j) are consented with the proposed structure. The elemental analysis (CHNS) was accomplished for synthesized compounds to confirm their basic chemical structures and revealed acceptable agreement with the calculated percentages.

Yayınlandığı Kaynak : Ankara Üniversitesi Eczacılık Fakültesi Dergisi
  • Yıl : 2020
  • DOI : 10.33483/jfpau.620599
  • Cilt : 44
  • ISSN : 1015-3918
  • Sayı : 1
  • Sayfa Aralığı : 89-98
  • IO Kayıt No : 110154
  • Yayıncı : Ankara Üniversitesi Eczacılık Fakültesi