Merhaba Misafir

Vitamin D receptor and collagen type1α1 gene polymorphisms in patients with postmenauposal osteoporosis

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Purpose: The iam of this study was to investigate the genotype and allele frequencies of osteoporosis related candidate genes, VDR and COL1A1 and their relationship between biochemical and anatomic parameters in patients with postmenopausal osteoporosis and healthy women in the Cukurova region of Turkey. Materials and Methods: Eighty-four postmenopausal osteoporotic patients and fourty-five controls were recruited after obtaining informed consent. Four polymorphic restriction sites (ApaI, TaqI, BsmI and FokI) for the VDR gene and two polymorphic restriction sites (Sp1 and -1997G/T) for the COL1A1 gene were examined. All subjects were genotyped employing polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of VDR and COL1A1 polymorphism genotypes, alleles and haplotypes were not statistically significant between patients and controls. The VDR gene BsmI, ApaI and TaqI polymorphisms, and the COL1A1 -1997G/T and Sp1 polymorphisms had a strong linkage disequilibrium. The most common haplotypes were “BAt” for patients and “baT” for controls in the VDR gene, the “TG” haplotype (also “TS”) was the most common in two groups for COL1A1 gene. Conclusion: The VDR and COL1A1 gene polymorphisms play key roles in osteoporosis susceptibility and BMD in postmenopausal women. Our findings may imply that polymorphisms of the VDR and COL1A1 genes were not associated with low BMD or fractures in postmenopausal Turkish women.

Yayınlandığı Kaynak : Cukurova Medical Journal
  • Yıl : 2019
  • DOI : 10.17826/cumj.463628
  • Cilt : 44
  • ISSN : 2602-3032
  • Sayı : 3
  • eISSN : 2602-3040
  • Sayfa Aralığı : 936-946
  • IO Kayıt No : 102762
  • Yayıncı : Çukurova Üniversitesi Tıp Fakültesi