Merhaba Misafir

The value of VEGF and IGF-1 in the diagnosis retinopathy of prematurity and follow-up of response to laser therapy


Purpose: Early recognition of the retinopathy of prematurity (ROP), timely and appropriate treatment will contribute to the developmental process of the infant and increase the quality of life by preventing vision loss. We here by aimed to figure out the value of the blood levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) in infants with severe ROP requiring laser therapy. Materials and Methods: Very low birth weight infants (VLBW, ≤1500 g and gestational age ≤32 weeks) were included in the study. Blood samples for the evaluation of markers were obtained from the cord at birth for all preterms and at the same postpartum corrected age (34 weeks) for ROP and control group. Results: The mean serum VEGF level was 185.6 ± 88.1 pg/mL in the control group and 590.2 ± 97.4 pg/mL before laser treatment in the ROP group . It was decreased to 83.7 ± 25.4 pg/mL at 4 day after laser treatment in the ROP group). No significant difference was existed between the values of IGF-1 before and after laser treatment in infants with severe ROP. Conclusion: Serum VEGF and IGF-1 levels may be suggested as a sensitive marker of severe ROP. Additionally, the decrease in serum levels of VEGF after laser therapy can be used as an indicator for the efficacy of laser treatment.

Yayınlandığı Kaynak : Cukurova Medical Journal
  • Yıl : 2019
  • DOI : 10.17826/cumj.472840
  • Cilt : 44
  • ISSN : 2602-3032
  • Sayı : 3
  • eISSN : 2602-3040
  • Sayfa Aralığı : 745-752
  • IO Kayıt No : 102708
  • Yayıncı : Çukurova Üniversitesi Tıp Fakültesi